See why the development of psilocin solids is an expanding and exciting field.
The resurgence of psychedelic research over the past two decades has yielded promising results for the treatment of numerous mental health conditions such as anxiety, addiction and PTSD. Upon ingestion of prodrug psilocybin, the most widely studied psychedelic molecule, it is metabolized to psilocin the active metabolite responsible for delivering therapeutic benefit. Thus, it would make sense to administer psilocin directly to, reduce the onset time of action, enhance dose consistencies, and provide improved delivery methods such as transdermal and/or sublingual.
However, psilocin’s chemical and physical stability limitations have hampered its development. In attempts to overcome these molecular challenges, organic salts of psilocin are being created to provide the necessary chemical enhancements. These new inventions are also protectable providing additional benefit to the technical discoveries through the filing of intellectual property. Herein, 3 novel salts of psilocin (all GRAS counterions) have been created and patents (US and PCT) filed.
1) Faster onset/shorter duration
Estimated psilocin half life ranges from 1-2 hours compared to psilocybin 2-4 hours
Reduced time in clinic and quicker recovery
2) Consistent dosing
Metabolism rates vary in individuals, so removing the dephosphorylation step experiences can occur more consistently
Eliminates the variability of the experience
3) Improved delivery methods
Conversion in the gut is not necessary
Sublingual and transdermal delivery are potential options
Filament Health – reported obtaining FDA-approval for the 1st phase 1 human trial with psilocin in 2021
3 salts of psilocin were created and intellectual property filed!
There have been 10 clinical trials of psilocin since 2021.
Filament Health – reported obtaining FDA-approval for the 1st phase 1 human trial with psilocin in 2021.
3 salts of psilocin were created and intellectual property filed!
Crystalline Salts of Psilocin
Stearic Acid
Malic Acid
Nicotinic Acid
Stearic Acid
Stearic Acid
Stearic Acid
Stearic Acid
Stearic Acid
Stearate
Malate
Nicotinate
Stearate
Stearate
Stearate
Stearate
Stearate
U.S.
U.S.
U.S.
Japan
Canada
China
EPO
India
11,970,447
2024/0199545
2024/0246912
7594330
3219041
2022800497430
22732751.7
202317088364
05/24/2022
02/29/2024
02/29/2024
05/24/2022
05/24/2022
05/24/2022
05/24/2022
05/24/2022
04/30/2024
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11/26/2024
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Granted
Pending***
Pending***
Granted
Pending
Pending
Pending
Pending
* The nicotinate salt filing has a prioritydate of 05/24/2021 and the stearate and malate salts is 02/16/2022
** Granted patents have a term of 20 years fromthe non-provisional filing date
*** USPTO approved applications for granting3/1/2025