Psilocin Solid Forms

See why the development of psilocin solids is an expanding and exciting field.

Psychedelic Solids Abstract

The resurgence of psychedelic research over the past two decades has yielded promising results for the treatment of numerous mental health conditions such as anxiety, addiction and PTSD. Upon ingestion of prodrug psilocybin, the most widely studied psychedelic molecule, it is metabolized to psilocin the active metabolite responsible for delivering therapeutic benefit. Thus, it would make sense to administer psilocin directly to, reduce the onset time of action,  enhance dose consistencies, and provide improved delivery methods such as transdermal and/or sublingual.

However, psilocin’s chemical and physical stability limitations have hampered its development.  In attempts to overcome these molecular challenges, organic salts of psilocin are being created to provide the necessary chemical enhancements. These new inventions are also protectable providing additional benefit to the technical discoveries through the filing of intellectual property. Herein, 3 novel salts of psilocin (all GRAS counterions) have been created and patents (US and PCT) filed.

Benefits of Psilocin

Attribute
Description
Benefit

1) Faster onset/shorter duration

Estimated psilocin half life ranges from 1-2 hours compared to psilocybin 2-4 hours

Reduced time in clinic and quicker recovery

2) Consistent dosing

Metabolism rates vary in individuals, so removing the dephosphorylation step experiences can occur more consistently

Eliminates the variability of the experience

3) Improved delivery methods

Conversion in the gut is not necessary

Sublingual and transdermal delivery are potential options

10 clinical trials of psilocin since 2021

Filament Health – reported obtaining FDA-approval for the 1st phase 1 human trial with psilocin in 2021

Existing Hurdles for Psilocin

  • Natural products are not patentable
  • Free base is unstable to air, heat and light

Solutions

  • New solid forms of psilocin are patentable, granting exclusive rights to the IP holders
  • Salts (solid forms) often lead to improved physical and chemical properties

3 salts of psilocin were created and intellectual property filed!

Psilocin Development

There have been 10 clinical trials of psilocin since 2021.
Filament Health – reported obtaining FDA-approval for the 1st phase 1 human trial with psilocin in 2021.

  • Natural products are not patentable
  • Free base is unstable to air, heat and light
  • New solid forms of psilocin are patentable, granting exclusive rights to the IP holders
  • Salts (solid forms) often lead to improved physical and chemical properties

3 salts of psilocin were created and intellectual property filed!

Intellectual Property

Crystalline Salts of Psilocin

Carboxylic Acid

Stearic Acid

Malic Acid

Nicotinic Acid

Stearic Acid

Stearic Acid

Stearic Acid

Stearic Acid

Stearic Acid

Counterion

Stearate

Malate

Nicotinate

Stearate

Stearate

Stearate

Stearate

Stearate

Country

U.S.

U.S.

U.S.

Japan

Canada

China

EPO

India

Patent No.

11,970,447

2024/0199545

2024/0246912

7594330

3219041

2022800497430

22732751.7

202317088364

Date Filed

05/24/2022

02/29/2024

02/29/2024

05/24/2022

05/24/2022

05/24/2022

05/24/2022

05/24/2022

Issue Date

04/30/2024

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11/26/2024

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Status**

Granted

Pending***

Pending***

Granted

Pending

Pending

Pending

Pending

*     The nicotinate salt filing has a prioritydate of 05/24/2021 and the stearate and malate salts is 02/16/2022
**   Granted patents have a term of 20 years fromthe non-provisional filing date
***  USPTO approved applications for granting3/1/2025

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